Adsorption of tetrakis(4-sulfophenyl)porphyrin onto liposomal surfaces composed of neutral diacylphosphatidylcholine and release by cyclodextrin.

Anionic tetrakis(4-sulfophenyl)porphyrin (TPPS) interacts with liposomal surfaces composed of neutral diacylphosphatidylcholine at high lipid concentrations. TPPS interacted with liposomal surfaces through four contact points. The association constant was obtained to be 9.0 × 10 5 M -4 . TPPS was peeled off the liposomal surfaces by the addition of cyclodextrin.