The association between <i>N</i>-methyl-d-aspartate receptor availability and glutamate levels: A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls.
Katherine BeckAtheeshaan ArumuhamStefan BruggerRobert A McCutcheonMattia VeroneseBarbara SantangeloColm J McGinnityJoel DunnStephen J KaarNisha SinghToby PillingerFaith BorganTeresa SementaRadhouene NejiSameer JauharFranklin AigbirhioIstvan BorosFederico TurkheimerAlexander HammersDavid LythgoeJames M StoneOliver D HowesPublished in: Journal of psychopharmacology (Oxford, England) (2022)
This study show that lower relative NMDAR availability in the hippocampus may drive increased striatal glutamate levels in patients with schizophrenia. Further work is required to determine whether these findings may yield new targets for drug development in schizophrenia.