Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia.
Aparecida Gabriela Bexiga VelosoNathalia Edviges Alves LimaElisabete de Marco OrnelasClever Gomes CardosoMara Rubia MarquesBeatriz da Costa Aguiar Alves ReisFernando Luiz Affonso FonsecaLaura Beatriz Mesiano MaifrinoPublished in: Medical molecular morphology (2018)
Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized LDL-R knockout; sedentary ovariectomized LDL-R knockout; and trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.
Keyphrases
- bone loss
- physical activity
- low density lipoprotein
- primary care
- high intensity
- blood glucose
- healthcare
- adipose tissue
- resistance training
- quality improvement
- wild type
- postmenopausal women
- pulmonary hypertension
- high fat diet
- blood pressure
- left ventricular
- pregnant women
- body composition
- type diabetes
- skeletal muscle