Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).
Matthew TraylorDaniel J TozerIain D CroallDanuta M Lisiecka-FordAbiodun Olubunmi OlorundaGiorgio BoncoraglioMartin DichgansRobin LemmensJonathan RosandNatalia S RostPeter M RothwellCathie L M SudlowVincent N ThijsLoes C A Rutten-JacobsHugh S Markusnull nullPublished in: Neurology (2019)
Genetic variation in PLEKHG1 is associated with WMH and ischemic stroke, most strongly with the small vessel subtype, suggesting it acts by promoting small vessel arteriopathy.