Neurometabolic changes in neonates with congenital heart defects and their relation to neurodevelopmental outcome.

Céline StegerMaria FeldmannJulia BornsCornelia HagmannBeatrice LatalUlrike HeldAndrás JakabRuth O'Gorman TuuraWalter Knirsch

Published in: Pediatric research (2022)

NAA/Cho was reduced in the white matter, but not the gray matter of CHD neonates compared to healthy controls. No correlation to the 1-year neurodevelopmental outcome (Bayley-III) was found. While the rapid change of NAA/Cho with age might make it a sensitive marker for a delay in brain maturation, the relationship to neurodevelopmental outcome requires further investigation.

Keyphrases

white matter
low birth weight
multiple sclerosis
cerebral ischemia
loop mediated isothermal amplification