Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice.
Zheng HaoR Leigh TownsendMichael B MumphreyThomas W GettysSangho YuHeike MünzbergChristopher D MorrisonHans-Rudolf BerthoudPublished in: Obesity surgery (2019)
We conclude that bile acid signaling through TGR5 is not required for the beneficial effects of RYGB in the mouse and that RYGB and VSG may achieve their similar beneficial effects through different mechanisms.
Keyphrases
- roux en y gastric bypass
- weight loss
- gastric bypass
- bariatric surgery
- obese patients
- minimally invasive
- coronary artery bypass
- high glucose
- diabetic rats
- wild type
- high fat diet induced
- glycemic control
- drug induced
- weight gain
- type diabetes
- skeletal muscle
- coronary artery disease
- acute coronary syndrome
- body mass index
- adipose tissue
- stress induced