Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance.

Wei ZhangJingxin ZhangChenzhou XuShiqing ZhangSaiyan BianFeng JiangWenkai NiLishuai QuCuihua LuRunzhou NiYihui FanMingbing XiaoJin-Xia Liu

Published in: Cancer cell international (2020)

We demonstrate a critical role of USP7 in HCC devolvement and chemoresistance. Disruption of USP7 function results in dis-regulated several key biological processes and subsequently activates BAX. USP7 might be a novel and drug-able target in HCC.

Keyphrases

adverse drug
small molecule
transcription factor
drug induced
emergency department
cancer stem cells
induced apoptosis
oxidative stress
signaling pathway
endoplasmic reticulum stress