Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells.

Cherry S LeungKevin Y YangXisheng LiVicken W ChanManching KuHerman WaldmannShohei HoriJason C H TsangYuk Ming Dennis LoKathy O Lui

Published in: Genome medicine (2018)

Our results suggest that short-term coreceptor and costimulation blockade mediates immune tolerance to hESC-derived pancreatic islets by promoting Treg proliferation through engagement of PD-1. Our findings could give new insights into clinical development of hESC-derived pancreatic tissues, combined with immunotherapies that expand intragraft Treg, as a potentially sustainable alternative treatment for T1D.

Keyphrases

single cell
regulatory t cells
rna seq
signaling pathway
dendritic cells
high throughput
gene expression
immune response