Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length.
Claire F McGroderDavid ZhangMohammad A ChoudhuryMary M SalvatoreBelinda M D'SouzaEric A HoffmanYing WeiMatthew R BaldwinChristine Kim GarciaPublished in: Thorax (2021)
The risk factors for development of fibrotic-like radiographic abnormalities after severe COVID-19 are incompletely described and the extent to which CT findings correlate with symptoms and physical function after hospitalisation remains unclear. At 4 months after hospitalisation, fibrotic-like patterns were more common in those who underwent mechanical ventilation (72%) than in those who did not (20%). We demonstrate that severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission and leucocyte telomere length are independent risk factors for fibrotic-like radiographic abnormalities. These fibrotic-like changes correlate with lung function, cough and measures of frailty, but not with dyspnoea.
Keyphrases
- mechanical ventilation
- lung function
- acute respiratory distress syndrome
- systemic sclerosis
- intensive care unit
- idiopathic pulmonary fibrosis
- coronavirus disease
- sars cov
- pulmonary fibrosis
- respiratory failure
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- extracorporeal membrane oxygenation
- emergency department
- physical activity
- computed tomography
- magnetic resonance imaging
- respiratory syndrome coronavirus
- magnetic resonance
- contrast enhanced
- depressive symptoms
- sleep quality
- community dwelling