Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway.

Ayodeji Johnson AjibareAdeyemi Fatai OdetayoOlabode Oluwadare AkintoyeLuqman Aribidesi Olayaki

Published in: Redox report : communications in free radical research (2024)

In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.

Keyphrases

induced apoptosis
oxidative stress
diabetic rats
cell cycle arrest
pi k akt
anti inflammatory
signaling pathway
endoplasmic reticulum stress
oxide nanoparticles
germ cell
high glucose
cell death
hydrogen peroxide
mouse model
epithelial mesenchymal transition
nitric oxide