Puerarin protects fibroblasts against mechanical stretching injury through Nrf2/TGF-β1 signaling pathway.

Yang LiCheng LiuLian YangLu LiLi Hong

Published in: International urogynecology journal (2022)

Puerarin protected fibroblasts from mechanical injury-induced ECM remodeling through the Nrf2/TGF-β1 signaling pathway. This might be a new strategy for the treatment of SUI.

Keyphrases

signaling pathway
extracellular matrix
transforming growth factor
oxidative stress
pi k akt
epithelial mesenchymal transition
diabetic rats
induced apoptosis
high glucose
cell proliferation
endothelial cells