Amplification of Cardioprotective Response of Remote Ischemic Preconditioning in Rats by Quercetin: Potential Role of Activation of mTOR-dependent Autophagy and Nrf2.

Ayush KandpalKuldeep KumarSatnam SinghHarlokesh Narayan YadavAmteshwar Singh JaggiDhandeep SinghDimple Sethi ChopraLeonid MaslovNirmal Singh

Published in: Cardiovascular drugs and therapy (2024)

The findings highlight the modification of the cardioprotective effect of RIPC by quercetin and that quercetin protects the heart against MIRI through multiple mechanisms, including mTOR-dependent activation of autophagy and Nrf-2 activation.

Keyphrases

oxidative stress
cell death
signaling pathway
ischemia reperfusion injury
cell proliferation
endoplasmic reticulum stress
heart failure
climate change
blood brain barrier