Nucleophilic Allylation of Acylsilanes in Water: An Effective Alternative to Functionalized Tertiary α-Silylalcohols.
Xiu-Xia LiangChen ZhuWang ZhangYa-Nan DuLei XuLihua LiuYicheng ZhangMan-Yi HanPublished in: The Journal of organic chemistry (2023)
A nucleophilic allylation of acylsilanes in water was developed, generating versatile functionalized tertiary α-silyl alcohols in high yields. With the assistance of hydrogen bonding, a reaction model of less reactive acylsilane was achieved. Unlike the conventional strategy, transition metals and an additional Lewis acid catalyst were not required, and rate acceleration was observed in water.