Preclinical evaluation of efficacy and pharmacokinetics of gentamicin containing extracellular-matrix envelope.

Muhammad Rizwan Sohail Zerelda Esquer GarrigosClaude S ElayiKun XiangJohn N Catanzaro

Published in: Pacing and clinical electrophysiology : PACE (2020)

In this preclinical animal infection model, gentamicin containing ECME was highly effective in reducing bacterial burden in the implant pocket, while systemic exposure after implantation remained low.

Keyphrases

extracellular matrix
cell therapy
soft tissue
risk factors
bone marrow
drug induced