Improved diagnostic stratification of digitised Barrett's oesophagus biopsies by p53 immunohistochemical staining.
Myrtle J van der WelLucas C DuitsRoos E PouwCornelis A SeldenrijkG J A OfferhausMike VisserFiebo J Ten KateKatharina BiermannLodewijk A A BrosensMichael DoukasClement HuysentruytArend KarrenbeldGursah Kats-UgurluJaap S van der LaanG Ineke van LijnschotenFreek C P MollAriadne H A G OomsHans van der ValkJan G TijssenJacques J BergmanSybren L MeijerPublished in: Histopathology (2018)
Addition of p53 IHC significantly improves the histological assessment of BO biopsies, even within a group of dedicated GI pathologists. It decreases the proportion of IND diagnoses, and increases interobserver agreement and diagnostic accuracy. This justifies the use of accessory p53 IHC within our upcoming national digital review panel for BO biopsy cases.