Prenatal Alcohol Exposure Increases Histamine H3 Receptor-Mediated Inhibition of Glutamatergic Neurotransmission in Rat Dentate Gyrus.

Rafael K VaraschinNyika A AllenMartina J RosenbergC Fernando ValenzuelaDaniel D Savage

Published in: Alcoholism, clinical and experimental research (2018)

These results suggest that a PAE-induced elevation in H3 receptor-mediated inhibition of glutamate release from perforant path terminals as 1 mechanism contributing the LTP deficits previously observed in the dentate gyrus of PAE rats, as well as providing a mechanistic basis for the efficacy of H3 receptor inverse agonists for ameliorating these deficits.

Keyphrases

traumatic brain injury
high glucose
pregnant women
oxidative stress
diabetic rats
drug induced
endothelial cells
stress induced