Designing Nanocomposite-Based Electrochemical Biosensors for Diabetes Mellitus Detection: A Review.
Xiang GuoJiaxin WangJinyan BuHuichao ZhangMuhammad ArshadAyesha KanwalMuhammad K MajeedWu-Xing ChenKuldeep K SaxenaHongchao MaPublished in: ACS omega (2024)
This review will unveil the development of a new generation of electrochemical sensors utilizing a transition-metal-oxide-based nanocomposite with varying morphology. There has been considerable discussion on the role of transition metal oxide-based nanocomposite, including iron, nickel, copper, cobalt, zinc, platinum, manganese, conducting polymers, and their composites, in electrochemical and biosensing applications. Utilizing these materials to detect glucose and hydrogen peroxide selectively and sensitively with the correct chemical functionalization is possible. These transition metals and their oxide nanoparticles offer a potential method for electrode modification in sensors. Nanotechnology has made it feasible to develop nanostructured materials for glucose and H 2 O 2 biosensor applications. Highly sensitive and selective biosensors with a low detection limit can detect biomolecules at nanomolar to picomolar (10 -9 to 10 -12 molar) concentrations to assess physiological and metabolic parameters. By mixing carbon-based materials (graphene oxide) with inorganic nanoparticles, nanocomposite biosensor devices with increased sensitivity can be made using semiconducting nanoparticles, quantum dots, organic polymers, and biomolecules.
Keyphrases
- label free
- oxide nanoparticles
- reduced graphene oxide
- transition metal
- quantum dots
- hydrogen peroxide
- gold nanoparticles
- carbon nanotubes
- visible light
- sensitive detection
- nitric oxide
- blood glucose
- human health
- solid phase extraction
- low cost
- energy transfer
- type diabetes
- ionic liquid
- molecularly imprinted
- water soluble
- health risk
- mass spectrometry
- drinking water
- blood pressure
- highly efficient
- simultaneous determination
- liquid chromatography