New dammarane-type triterpenoids from Aglaia elliptica (C.DC.) blume.

Three new dammarane-type triterpenoids, namely elliptaglin A-C ( 1 - 3 ) were isolated from the stem bark of Aglaia elliptica (C.DC.) Blume along with three known derivatives, namely (20 S )-hydroxydammar-24-en-3-on ( 4 ), cabralealactone ( 5 ), and E -25-hydroperoxydammar-23-en-20-ol-3-one ( 6 ). Subsequently, their chemical structures were determined using HR-ESI-MS, FTIR, 1D and 2D-NMR spectroscopic analysis as well as comparison with previous studies. The cytotoxicity activities of the isolated compounds against MCF-7 breast cancer and B16-F10 melanoma cell lines were then tested using PrestoBlue reagent. The analysis results showed that elliptaglin B ( 2 ) had the strongest activity against both cell lines with IC 50 values of 60.98 and 51.83 µM, respectively.