Atroposelective Synthesis of N-N Axially Chiral Bipyrroles via Rhodium-Catalyzed C-H Insertion Reaction.

An atroposelective synthesis of bipyrroles with an axially chiral N-N bond has been established via a rhodium-catalyzed C-H bond insertion reaction to provide the desired atropisomers in good yields (up to 97% yield) with good to excellent enantioselectivities (up to 99% ee).