Myeloid-specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage.

Xiao HanJianbo NiZengkai WuJianghong WuBin LiXin YeJuanjuan DaiCongying ChenJing XueRong WanLi WenXingpeng WangGuoyong Hu

Published in: British journal of pharmacology (2020)

Our data for the first time showed that myeloid-specific D2 receptor signalling controls pancreatic injury and systemic inflammation via inhibiting M1 macrophage, suggesting D2 receptor activation might serve as therapeutic target for AP.

Keyphrases

signaling pathway
dendritic cells
bone marrow
adipose tissue
acute myeloid leukemia
oxidative stress
transcription factor
electronic health record
big data
artificial intelligence
data analysis