Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors.
Michael LutterEthan BahlClaire HannahDabney HofammannSummer AcevedoHuxing CuiCarrie J McAdamsJacob J MichaelsonPublished in: PloS one (2017)
These findings implicate ultra-rare and novel damaging variants in neuropeptide/neurotropic factor signaling pathways in the development of eating disorder behaviors and identify glucagon-like peptide 1-receptor agonists as a potential treatment for binge eating.