Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway.

Yang ZhaoYi-Han WangWei-Chao TuDa-Wei WangMu-Jun LuYuan Shao

Published in: Drug design, development and therapy (2024)

This study demonstrates that CTD could mitigate renal fibrosis, ferroptosis and inflammation in CKD by modulating the IKKβ/NF-κB pathway, which indicates targeting IKKβ has an enormous potential for treating CKD.

Keyphrases

chronic kidney disease
signaling pathway
end stage renal disease
oxidative stress
lps induced
pi k akt
nuclear factor
cell death
inflammatory response
risk assessment
cell proliferation
drug delivery
climate change