Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer.

Mustafa Emre Gedik Ozge Saatci Nathaniel Oberholtzer Meral Uner Ozge Akbulut-Caliskan Metin Cetin Mertkaya Aras Kubra Ibis Burcu Çalışkan Erden Banoglu Stefan Wiemann Aysegül Uner Sercan Aksoy Shikhar Mehrotra Özgür Sahin

Published in: Cancer research (2024)

Loss of induction of immunogenic cell death in response to T-DM1 leads to resistance that can be overcome by targeting TACC3, providing an attractive strategy to improve the efficacy of T-DM1.

Keyphrases

cell death
positive breast cancer
cell cycle arrest
glycemic control
cancer therapy
type diabetes
cell proliferation