Whole-Exome Sequencing Analysis of the Progression from Non-Low-Grade Ductal Carcinoma In Situ to Invasive Ductal Carcinoma.

Fresia ParejaDavid N BrownJu Youn LeeArnaud Da Cruz PaulaPier SelenicaRui BiFelipe C GeyerAndrea GazzoEdaise M da SilvaMahsa VahdatiniaAnthe A StylianouLorenzo FerrandoHannah Y WenJames B HicksBritta WeigeltJorge S Reis-Filho

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Intralesion genetic heterogeneity is a common feature in DCIS synchronously diagnosed with IDC-NST. DCIS is a nonobligate precursor of IDC-NST, whose mechanisms of progression to invasive breast cancer are diverse and vary from case to case.

Keyphrases

low grade
high grade
machine learning
single cell
genome wide
gene expression
dna methylation