Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD.

Hani ShamseddeenAbhishek MadathanapalliVijay S AreVijay H ShahArun J SanyalQing TangTiebing LiangKayla GelowTeresa A ZimmersNaga ChalasaniArchita P Desai

Published in: Digestive diseases and sciences (2020)

Myostatin levels are significantly lower in AH compared to HD and are negatively correlated with total bilirubin, WBC, and platelet count. Myostatin increased as patients experienced decreases in MELD. Overall, myostatin demonstrated a dynamic relationship with AH outcomes and future studies are needed to understand the prognostic role of myostatin in AH.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
type diabetes
current status
skeletal muscle
patient reported outcomes
insulin resistance
glycemic control