Mussel-Inspired Tantalum Nanocomposite Hydrogels for In Situ Oral Cancer Treatment.
Maoru ZhaoChao JiHao DaiChengyan WangRuixue LiuJiani XieYuguang WangZhanjun GuPublished in: ACS applied materials & interfaces (2023)
Oral squamous cell carcinoma (OSCC) is one of the most common oral malignancies. Radiotherapy is the primary noninvasive treatment of OSCC for avoiding surgery-induced facial deformities and impaired oral function. However, the specificity of in situ OSCC limits radiotherapeutic effects because of the hypoxia-induced low radiosensitivity of tumors and the low radiation tolerance of surrounding normal tissues. Here, we design a highly efficient and low-toxic radiosensitization strategy. On the one hand, biocompatible poly(vinyl pyrrolidone)-modified tantalum nanoparticles (Ta@PVP NPs) not only have strong X-ray deposition capability to upregulate oxidative stress but also have photothermal conversion efficiency to improve hypoxia for tumor radiosensitivity. On the other hand, to optimize the spatial distribution of Ta@PVP NPs within tumors, mussel-inspired catechol with bioadhesive properties is grafted on tumor microenvironment-responsive sodium alginate (DAA) to form in situ hydrogels for precision radiotherapy. On this basis, we find that Ta@PVP-DAA hydrogels effectively inhibit OSCC development in mice under photothermal-assisted radiotherapy without facial deformities and damage to surrounding normal tissues. Overall, our work not only promotes the exploration of Ta@PVP NPs as new radiosensitizers for OSCC but also develops a nanocomposite hydrogel system strategy as a promising paradigm for the precision treatment of orthotopic tumors.
Keyphrases
- drug delivery
- highly efficient
- drug release
- oxidative stress
- early stage
- cancer therapy
- hyaluronic acid
- tissue engineering
- radiation induced
- locally advanced
- radiation therapy
- wound healing
- gene expression
- minimally invasive
- photodynamic therapy
- high resolution
- diabetic rats
- extracellular matrix
- type diabetes
- dna damage
- squamous cell carcinoma
- computed tomography
- high glucose
- soft tissue
- skeletal muscle
- rectal cancer
- oxide nanoparticles
- stress induced
- mass spectrometry
- replacement therapy