Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia.
Zhihao XingHuirong MaiXiaorong LiuXiaoying FuXingliang ZhangLichun XieYunsheng ChenAdam ShlienFei-Qiu WenPublished in: Genome biology (2022)
Our results demonstrate KMT2A partners and CRGs may form dynamic and multipartite spatial clusters in individual cells that may be involved in RUNX1-mediated transcription factories, wherein massive DNA damages and illegitimate ligations of genes may occur, leading to complex rearrangements and KMT2A fusions in leukemia.
Keyphrases
- single cell
- acute myeloid leukemia
- induced apoptosis
- bone marrow
- transcription factor
- cell cycle arrest
- rna seq
- circulating tumor
- genome wide
- cell free
- single molecule
- high throughput
- signaling pathway
- gene expression
- endoplasmic reticulum stress
- dna methylation
- hepatitis c virus
- genome wide analysis
- hiv infected
- circulating tumor cells