Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury.

Jingyi MiYang YangHao YaoZhirong HuanCe XuZhiheng RenWenfu Li Ying Tang Rao FuXin Ge

Published in: Journal of neuroinflammation (2021)

Our findings indicate that knockdown of HSPA8 inhibits spinal astrocytic damage after SCII, which may provide a promising therapeutic strategy for SCII treatment.

Keyphrases

heat shock protein
ischemia reperfusion injury
spinal cord
nlrp inflammasome
oxidative stress
heat shock
spinal cord injury
neuropathic pain
signaling pathway
lps induced
inflammatory response
nuclear factor