Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells.

Vladimir Vladimirovich MuzykaMatthew BrooksTudor Constantin Badea

Published in: Neural development (2018)

Amongst our candidate Brn3a target genes, a majority demonstrated ganglion cell layer specificity, however only around two thirds showed Brn3a dependency. Some were previously implicated in RGC type specification, while others have known physiological functions in RGCs. Only three genes were found to be consistently regulated by Brn3a throughout postnatal retina development - Mapk10, Tusc5 and Cdh4.

Keyphrases

genome wide
preterm infants
bioinformatics analysis
genome wide identification
induced apoptosis
signaling pathway
cell fate
neuropathic pain
cell therapy
mesenchymal stem cells
spinal cord
transcription factor
endoplasmic reticulum stress
optical coherence tomography