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Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review.

Michael AbouyannisDinesh AggarwalDavid Griffith LallooNicholas R CasewellMainga M HamalubaHanif Esmail
Published in: PLoS neglected tropical diseases (2021)
Significant heterogeneity in outcome measures exists in snakebite clinical trials. Consensus is needed to select outcome measures that are valid, reliable, patient-centred and feasible. The results of this systematic review strongly support the development of a core outcome set for use in snakebite clinical trials.
Keyphrases
  • clinical trial
  • systematic review
  • meta analyses
  • phase ii
  • case report
  • single cell
  • phase iii
  • open label
  • study protocol
  • double blind
  • combination therapy
  • replacement therapy