Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction.
Nur Shabrina AmirruddinWei Xuan TanYaw Sing TanDaphne Su-Lyn GardnerYong Mong BeeChandra Shekhar VermaShawn HoonKok Onn LeeAdrian Kee Keong TeoPublished in: Diabetologia (2021)
The results provide deeper insights into the mechanisms of beta cell failure during INS mutation-mediated diabetes disease progression. Decreasing spliced X-box binding protein 1 (sXBP1) or inflammatory response could be avenues to restore the function of the remaining WT INS allele.
Keyphrases
- endoplasmic reticulum stress
- binding protein
- inflammatory response
- type diabetes
- single cell
- induced apoptosis
- cell therapy
- endothelial cells
- multiple sclerosis
- cardiovascular disease
- glycemic control
- lipopolysaccharide induced
- transcription factor
- oxidative stress
- metabolic syndrome
- stem cells
- signaling pathway
- mesenchymal stem cells
- induced pluripotent stem cells
- weight loss