Evaluation of the safety and tolerability of spironolactone in patients with heart failure and chronic kidney disease.
Amanda R BuckallewKatie B TellorRachel WatsonWilliam MillerGina MbachuCameron WhitlockJay R SeltzerAnastasia L ArmbrusterPublished in: European journal of clinical pharmacology (2021)
Spironolactone may be safe to initiate in hospitalized patients with HF and CKD; however, appropriateness of therapy must be assessed upon admission to the hospital. Larger studies are needed for conclusive results.