Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol.
Marion RingelNicole DimosStephanie HimpichMartina HaackClaudia HuberWolfgang EisenreichHaruhiko FuwaBernhard LollThomas Bartholomäus BrückPublished in: Microbial cell factories (2022)
The presented product selectivity and titers of Copu5 and Copu9 may pave the way towards a sustainable, biotechnological production of the potentially new bioactive (+)-δ-cadinol. Furthermore, Copu5 and Copu9 may serve as model systems for further mechanistic studies of terpenoid catalysis.