Spatiotemporally deciphering the mysterious mechanism of persistent HPV-induced malignant transition and immune remodelling from HPV-infected normal cervix, precancer to cervical cancer: Integrating single-cell RNA-sequencing and spatial transcriptome.

Chenyan GuoXinyu QuXiaoyan TangYu SongJue WangKe-Qin HuaJunjun Qiu

Published in: Clinical and translational medicine (2023)

Together, these findings provided novel possibilities for accurate diagnosis, precise treatment and prognosis evaluation of patients with precancer and cervical cancer.

Keyphrases

single cell
rna seq
high grade
high throughput
high glucose
diabetic rats
cervical cancer screening
gene expression
high resolution
preterm birth
dna methylation
endothelial cells
combination therapy
stress induced