TERT Promoter Mutations and Their Impact on Gene Expression Profile in Papillary Thyroid Carcinoma.

Dagmara RusinekAleksandra PfeiferMarta CieslickaMalgorzata KowalskaAgnieszka PawlaczekJolanta KrajewskaSylwia Szpak-UlczokTomasz TyszkiewiczMonika HalczokAgnieszka CzarnieckaEwa Zembala-NozynskaMykola ChekanRoman LamchDaria Handkiewicz-JunakAleksandra LedwonEwa Paliczka-CieslikAleksandra KropinskaBarbara JarzabMalgorzata Oczko-Wojciechowska

Published in: Cancers (2020)

TERTp mutations are related to higher PTC aggressiveness. CRABP2 gene was validated as associated with TERTp mutations. However, its potential use in diagnostics or risk stratification in PTC patients needs further studies.

Keyphrases

gene expression
dna methylation
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
lymph node
prognostic factors
transcription factor
squamous cell carcinoma
patient reported outcomes