Repurposing an Antiepileptic Drug for the Treatment of Glioblastoma.

Anjali YadavAli AlnakhliHari Priya VemanaShraddha BhutkarAaron MuthVikas V Dukhande

Published in: Pharmaceutical research (2022)

Our results indicate that STP can be an effective GBM therapeutic that enhances the effects of TMZ on GBM cells. Importantly, STP reduced viability of TMZ-resistant cells. Our results warrant further studies in the mechanistic basis of STP's effects on GBM cells and the preclinical potential of STP in animal models.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
emergency department
cell death
oxidative stress
risk assessment
mesenchymal stem cells
bone marrow
climate change
human health
case control