Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in paracetamol-induced liver injury.

Patricia RiveraAntonio VargasAntoni Pastor Anna Boronat Antonio Jesús López-Gambero Laura Sánchez-Marín Dina Medina-Vera Antonia Serrano Francisco Javier Pavón Rafael de la Torre Ekaitz Agirregoitia María Isabel LucenaFernando Rodríguez de FonsecaJuan Decara Juan Suarez

Published in: British journal of pharmacology (2020)

The differential role of CB1 versus CB2 receptors on inflammatory/fibrogenic factors related to paracetamol-induced hepatotoxicity should be considered for designing alternative therapies against DILI.

Keyphrases

drug induced
oxidative stress
high glucose
anti inflammatory drugs
endothelial cells