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A novel experimental porcine model to assess the impact of differential pulmonary blood flow on ischemia-reperfusion injury after unilateral lung transplantation.

Anna Elisabeth FrickMichaela OrlitováArno VanstapelSofie OrdiesSandra ClaesDominique ScholsTobias HeiglJanne KaesBerta Saez-GimenezRobin VosGeert M VerledenBart VanaudenaerdeStijn E VerledenDirk E Van RaemdonckArne P Neyrinck
Published in: Intensive care medicine experimental (2021)
Partial clamping native pulmonary artery in large animal lung transplantation setting to study the impact of low versus high pulmonary flow on the development of ischemia reperfusion is feasible. In our study, differential blood flow had no effect on IRI. However, our findings might impact future studies with extracorporeal devices and represent a specific intra-operative problem during bilateral sequential single-lung transplantation.
Keyphrases
  • blood flow
  • pulmonary artery
  • pulmonary hypertension
  • extracorporeal membrane oxygenation
  • coronary artery
  • pulmonary arterial hypertension
  • oxidative stress
  • case report