AMP-activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis.

Cheng WangWencheng ZhangWenjing XuZhaoyu LiuKai Huang

Published in: Clinical and translational medicine (2022)

In conclusion, these observations suggest that hepatic AMPKα1 has an essential role in maintaining iron homeostasis by PHD2-dependent regulation of hepcidin, thus providing a potentially promising approach for the treatment of iron disturbances in chronic diseases.

Keyphrases

protein kinase
iron deficiency
skeletal muscle
combination therapy
smoking cessation