Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide.

Isabella GomesDaniel Antunes MorenoMariana Bisarro Dos ReisLuciane Sussuchi da SilvaLetícia Ferro LealGisele Melo GonçalvesCaio Augusto PereiraMarco Antônio OliveiraMarcus de Medeiros MatsushitaRui Manuel Vieira Reis

Published in: Journal of neuro-oncology (2021)

MGMT mRNA levels evaluated by digital expression were associated with the outcome of TMZ-treated GBM patients. The combination of MGMT methylation and mRNA expression may provide a more accurate prediction of TMZ response in GBM patients.

Keyphrases

newly diagnosed
end stage renal disease
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
binding protein
dna methylation
gene expression
high resolution
mass spectrometry
genome wide