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Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression.

Christophe Van BerckelaerC RypensP van DamL PouillonM ParizelK A SchatsM KockxW A A TjalmaP VermeulenS van LaereF BertucciC ColpaertL Dirix
Published in: Breast cancer research : BCR (2019)
IBC is characterised by poor survival and high PD-L1 immunoreactivity on sTIL. This suggests a role for PD1/PD-L1 inhibitors in the treatment of IBC. Furthermore, we showed that PD-L1 expression predicts response to neo-adjuvant therapy and that sTIL have prognostic significance in IBC.
Keyphrases
  • bone marrow
  • oxidative stress
  • free survival