Toll-like receptor 4 activation modulates pericardium-myocardium interactions in lipopolysaccharide-induced atrial arrhythmogenesis.

Fong-Jhih LinShao-Jung LiYen-Yu LuWen-Shiann WuYao-Chang ChenShih-Ann ChenYi-Jen Chen

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)

Healthy and inflamed pericardium differently modulate LPS-induced atrial arrhythmogenesis. Targeting pericardium via TLR4 signalling may be a novel therapeutic strategy for AF.

Keyphrases

inflammatory response
toll like receptor
lipopolysaccharide induced
lps induced
atrial fibrillation
nuclear factor
left atrial
catheter ablation
heart failure
cancer therapy
immune response
left ventricular
drug delivery
mitral valve