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Risk Factors for Early Treatment Discontinuation Due to Toxicity Among Patients With Metastatic Castration-resistant Prostate Cancer Receiving Androgen Receptor-targeted Therapy.

Zakaria ChakraniGeorge MellgardNathaniel SaffranStephen McCroskeryNicole TaylorMann PatelBobby LiawMatthew GalskyWilliam K OhChe-Kai TsaoVaibhav G Patel
Published in: American journal of clinical oncology (2024)
Our work presents the first description of ART treatment discontinuation and its causes in the real-world setting, as well as patient-reported side effects. Most patients with mCRPC discontinued treatment due to the progression of disease and a minority of patients discontinued secondary to treatment toxicity. Initial multivariable analysis suggests that patient-reported weakness, falls, and rash were associated with a higher likelihood of treatment discontinuation due to toxicity. Early monitoring of this population can prolong the duration of treatment and prevent unnecessary treatment burden.
Keyphrases
  • squamous cell carcinoma
  • small cell lung cancer
  • combination therapy
  • ejection fraction
  • community dwelling