Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats.
Noemi Oliveira MonteiroTheresa de Moura MonteiroThalya Soares R NogueiraJacqueline Rodrigues CesarLara Pessanha S NascimentoKaroline Azerêdo CampeloGraziela Rangel SilveiraFernanda AntunesDaniela Barros de OliveiraAlmir Ribeiro de Carvalho JuniorRaimundo Braz FilhoIvo José Curcino VieiraPublished in: Molecules (Basel, Switzerland) (2022)
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum . Its structure was elucidated by the spectral data of 1 H and 13 C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced ( p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.