A clinical-radiomics nomogram may provide a personalized 90-day functional outcome assessment for spontaneous intracerebral hemorrhage.

• The proposed Rad-score was significantly associated with 90-day poor functional outcome in patients with sICH. • The clinical-radiomics nomogram showed satisfactory calibration and the most net benefit for discriminating 90-day poor outcome. • The clinical-radiomics nomogram may provide personalized risk assessment of 90-day functional outcome for sICH patients.