Left ventricular systolic dysfunction with concomitant bradyarrhythmia in a patient with POEMS syndrome: a case report.
Joo Hor TanMin Sen YewWenjie HuangKenny TanPublished in: European heart journal. Case reports (2021)
We describe the first case of LV systolic dysfunction with concomitant significant bradyarrhythmia in a patient with PS. CMR revealed evidence suggestive of LV myocardial oedema and/or possible early infiltration. VEGF overexpression could explain oedema-related LV dysfunction which reversed with adequate diuresis, as well as damage to the conduction system. Early cardiac amyloidosis, which can be associated with PS, is an important differential diagnosis. Pacemaker implantation, adequate diuresis, and definitive chemotherapy are key to the management of concomitant ventricular myocardial and electrical dysfunction in such rare case.
Keyphrases
- left ventricular
- oxidative stress
- heart failure
- hypertrophic cardiomyopathy
- rare case
- cardiac resynchronization therapy
- case report
- acute myocardial infarction
- left atrial
- aortic stenosis
- mitral valve
- blood pressure
- endothelial cells
- squamous cell carcinoma
- transcription factor
- locally advanced
- percutaneous coronary intervention
- vena cava
- drug induced
- chemotherapy induced