Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia.

Paula AparicioDavid Navarrete-VillanuevaAlba Gómez-CabelloTresa López-RoyoEnrique SantamaríaJoaquín Fernández-IrigoyenKarina AusínManuel ArrueboVictor SebastianGermán Vicente-RodríguezRosario OstaRaquel Manzano

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Our results support the determination of EV PF4 and C1R as plasma diagnostic biomarkers in sarcopenia and open the door to investigate the role of the content of these vesicles in the pathogeny of the disease.

Keyphrases

skeletal muscle
community dwelling
minimally invasive
genome wide
single cell
solid phase extraction
molecularly imprinted
label free
gene expression
liquid chromatography