Water-soluble bright NIR AIEgens with hybrid ROS for wash-free mitochondrial "off-on" imaging and photodynamic therapy.

Fang-Zhou XuCheng-Yun Wang Qi WangJian-Wei ZouYi-Jie QiaoZhi-Qian Guo Weijun Zhao Wei-Hong Zhu

Published in: Chemical communications (Cambridge, England) (2022)

Several aggregation-induced emission luminogens (AIEgens) with excellent water-solubility and near-infrared emission were designed and synthesized for wash-free "off-on" mitochondrial imaging and photodynamic therapy of HeLa cells. The AIEgen TEPP exhibits both bright near-infrared emission ( φ F = 17.8%) and high hybrid ROS productivity (including OH˙ and 1 O 2 ).

Keyphrases

photodynamic therapy
fluorescence imaging
water soluble
cell cycle arrest
high resolution
cell death
oxidative stress
induced apoptosis
dna damage
reactive oxygen species
climate change
solid state