First-in-human validation of enzymolysis clearance strategy for decreasing renal radioactivity using modified [ 68 Ga]Ga-HER2 Affibody.

We for the first time demonstrated that enzymolysis clearance strategy can effectively reduce renal radioactivity accumulation in humans. This strategy is expected to decrease renal radiation dose of peptide and small protein-based radiotracers, especially in the field of radionuclide therapy.