Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response.
Frederikke Petrine FliednerTrine Bjørnbo EngelHenrik H El-AliAnders Elias HansenAndreas KjaerPublished in: BMC cancer (2020)
Our findings demonstrate that DW-MRI can be used for non-invasive monitoring of radiation-induced changes in cell state during cancer therapy. ADC values reflect ex vivo cell density and correlates well with apoptotic state, and can hereby be described as a marker for the cell state after therapy and used as a non-invasive response marker.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- diffusion weighted
- single cell
- cell therapy
- cancer therapy
- diffusion weighted imaging
- computed tomography
- magnetic resonance
- cell death
- drug delivery
- squamous cell carcinoma
- stem cells
- mesenchymal stem cells
- young adults
- anti inflammatory
- lymph node metastasis
- childhood cancer